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Black or tarry stool, visible blood in the stool, vomiting blood, severe abdominal pain, unexplained weight loss, persistent fever, anemia, or progressive swallowing difficulty should be evaluated appropriately

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J Appl Physiol 110:774780 Clinicaltrials.gov

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Upon thawing, the benzyl alcohol may not properly reintegrate into the solution, leaving you with what is essentially just sterile water in some parts of the vial and a higher concentration of the preservative in others

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